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Photodynamic therapy utilising topical delta-aminolevulinic acid in non-melanoma skin malignancies of the eyelid and the periocular skin

机译：利用局部δ-氨基乙酰丙酸在眼睑和眼周皮肤的非黑色素皮肤恶性肿瘤中进行光动力疗法

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Purpose: Photodynamic therapy utilising delta-aminoleuvlinic acid-induced protoporphyrin IX photosensitisation, was evaluated as a treatment modality for nonmelanoma skin malignancies of the eyelids and the periocular skin, Methods: Photodynamic therapy with laser light at 635 nm was performed in 13 patients with 19 basal cell carcinomas and one patient with 3 cutaneous T-cell lymphoma lesions. A topical application regimen was used and in median 3 treatment sessions were given to each lesion. Results: A visually judged complete response was achieved in 42 % (8/19) of the basal cell carcinomas and in 100% of the T-cell lymphoma lesions (3/3), Partial tumour response was seen in 42% (8/19) and no response in 16% (3/19) of the basal cell carcinomas. The median follow-up time was 12 months. No, or very little scarring and loss of cilia were induced by the treatment. Conclusion: Photodynamic therapy with delta-aminolevulinic acid can eradicate eye-close non-melanoma skin malignancies without compromising the function of the eyelids. Further development of the method is needed to reach the same cure rates as those of the conventional treatment modalities.
机译：目的：评价利用δ-氨基丙酮酸诱导的原卟啉IX光敏化的光动力疗法作为眼睑和眼周皮肤非黑素瘤皮肤恶性肿瘤的治疗方式。方法：对13例19岁的患者进行了635 nm激光的光动力疗法。基底细胞癌和1例3例皮肤T细胞淋巴瘤病灶。使用局部应用方案，并在每个病变中位进行3次治疗。结果：在视觉判断的完全反应中，有42％（8/19）的基底细胞癌和100％的T细胞淋巴瘤病变（3/3）实现了部分肿瘤反应，在42％（8/19） 19），在16％（3/19）的基底细胞癌中无反应。中位随访时间为12个月。没有或很少的疤痕和纤毛的损失是由治疗引起的。结论：δ-氨基乙酰丙酸光动力疗法可以根除闭眼的非黑色素瘤皮肤恶性肿瘤，而不会损害眼睑的功能。需要对该方法进行进一步的开发以达到与常规治疗方式相同的治愈率。

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